Originally, the hospital in Mbozi was known as the Moravian Church Hospital and was founded by the Moravian Church in 1961. This hospital was a further development of the maternity clinic and attached orphanage founded by Sr. Elizabeth Senft in 1948. Then in 1960, under Rev. Hartmut Beck, additional buildings were constructed.
In 1974, the government approved the use of the hospital as a district hospital until 2001.

Since 2001, the hospital is again in the hands of the Moravian Church in the Southwest Province of Tanzania, since the state gave it back. The Moravian Church in Southwest Tanzania operates it on a voluntary basis to provide medical care to the people in the region.

Isoko Hospital in the district of Ileje was built and founded in 1950 as a hospital dispensary. In 1961, it was converted into a hospital with 50 beds. Today, the hospital has about 120 beds and employs a total of about 90 people. This facility provides the population in this poorly accessible area with the basic medical care they need. Isoko is a fully equipped facility with an operating room, a mother and child department with obstetrics and gynecology, emergency room, isolation ward and tuberculosis ward, an HIV clinic and a dental department.

The human right to the highest attainable standard of physical and mental health was formulated by the UN (United Nations) in 1966. It includes the safe and timely availability and accessibility of good quality health services to ensure basic care for major diseases. However, due to socio-political and economic conditions, many people in Africa still do not have access to modern medicine. Injustice and disadvantage are a reality. Especially in rural regions, there is a lack of good health facilities.

The core areas of Herrnhuter Missionshilfe's work have been defined as health work, strengthening health systems and improving the supply of medicines. For example, health care facilities have been established in areas with poor transportation so that the population can receive basic medical care such as treatment for acute illnesses or education (AIDS/HIV) when needed.

Herrnhuter Missionshilfe is strongly committed to health in cooperation with foundations and local organizations. It supports nursing schools where midwives, nurses, and orderlies are trained. Pharmacies and access to medical equipment and medicines are also promoted. Education and prevention are further important measures to contain diseases and to learn how to deal with them. The institutions supported by Herrnhuter Missionshilfe are repeatedly faced with the great challenge of having to procure or modernize medical equipment, renovate buildings or adapt premises.

All people in the respective regions benefit from the support in the area of health. The aim is to provide care for everyone who is ill, regardless of age, gender, ethnicity or nationality, insofar as human, material and financial resources are available. Another target group is the respective staff and doctors, who are to receive seminars, training and continuing education.